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Physicochemical features of compounds 1a, 2d and 3a based on Lipenski’s Rule of Five.
| Compounds | Molecular weight (Da) | No. Hbond donor | No. Hbond acceptor | LogP | Molecular refractivity |
|---|---|---|---|---|---|
| Lipenski’s rule | ≤ 500 | ≤ 5 | ≤ 10 | ≤ 5 | 40-130 |
| 1a | 346 | 0 | 4 | 0.94 | 81 |
| 2d | 282 | 1 | 4 | 2.34 | 70.43 |
| 3a | 420 | 3 | 6 | 3.6 | 111.79 |
