Table 3.

Evaluated IC50 values of monastrol’s derivatives for MCF-7 and HeLa cell lines and the ΔGbind. The IC50 valus are presented as mean ± SEM.

Derivatives	IC50 values		ΔG bind (kcal/mol)
	MCF-7 HeLa	HeLa
Monastrol	88 ± 23	111 ± 25	-6.67
M1	138 ± 6	160 ± 6	-6.34
M2	175 ± 20	224 ± 20	-6.09
M3	145 ± 3	232 ± 3	-5.67
M4	164 ± 21	220 ± 21	-8.01
M5	183 ± 22	262 ± 22	-6.24
M6	171 ± 15	217 ± 15	-7.16
D2	Not evaluated	Not evaluated	-6.90
M7	167 ± 1	270 ± 1	-3.05
M8	187 ± 5	225 ± 5	-6.51
M9	168 ± 15	228 ± 15	-7.29
M10	230 ± 63	249 ± 63	-5.53
M11	194 ± 30	266 ± 30	-8.63
M12	205 ± 13	> 500	-6.54