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| US CDC 2014 Diagnostic Criteria for NS | US CDC 2018 Diagnostic Criteria for NS | |
|---|---|---|
| Definite NS | Serum TPPA positive | Serum TPPA positive |
| CSF VDRL positive | Serum reactive RPR | |
| CSF VDRL positive | ||
| Probable NS | Serum reactive RPR | |
| Serum TPPA positive | Serum TPPA positive | |
| CSF WCC > 5 cell/microL | CSF WCC > 5 cell/microL | |
| or | or | |
| CSF protein > 0.5 mg/L | CSF protein > 0.5 mg/L |
