Figure 3. Increased uptake of c-FLFLF in AAA by fluorescence imaging of mice.
Near-infrared fluorescence imaging of c-FLFLF-Cy7 in live (shaved) anesthetized mice demonstrating aortic inflammation (elevated fluorescence) at the site of infrarenal AAA formation (see arrows) compared to controls on days 7 (A) and 14 (B). (C) Near-infrared fluorescence imaging of c-FLFLF-Cy7 in ex vivo aortic tissue demonstrating elevated fluorescence compared to controls on day14. (D) Fluorescence intensity (RFU; relative fluorescence units) in ex vivo aortic tissue was significantly increased on day 7 as well as on day 14 in elastase-treated mice (AAA) compared to respective controls. *P<0.05 vs. respective controls; #P<0.05 vs. Elastase Day 7; n=5 mice/group.
