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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Biomaterials. 2020 Feb 6;239:119842. doi: 10.1016/j.biomaterials.2020.119842

Figure 8. Oligodendrocyte depletion and demyelination increases visually-evoked coherence within and between different cortical layers.

Figure 8.

Normalized pairwise coherence, taken as the difference in coherence during visually-evoked and spontaneous activity, between cuprizone-treated and control animals at day 8 (a) and day 49 (b) post-insertion. Missing coherence values in (a) are an indication of lost information following electrode depth adjustment to layer IV. Evoked coherence between supragranular-infragranular (SG-IG), granular-infragranular (G-IG), and granular-supragranular (G-SG) regions over frequency between cuprizone-treated and control mice at day 8 (c) and day 49 (d) post-insertion. (e) Mean coherence between 7 and 90 Hz (shaded region of c and d), averaged across animals in each group. * indicates non-overlapping 95% confidence intervals at each time point as determined by likelihood ratio test applied to a linear mixed effects model for cuprizone-treated and control mice. Data presented as mean ± SEM.