TABLE 1.

Hazard ratios (HR) and 95% confidence intervals (CIs) for upper aerodigestive tract cancer risk according to variables included in the models

Model	Variable and categories	Number of cases	Number of subcohort subjects	HR	95% CIs	P value
Environmental model
	Age, y
	<50	20	1300	1.00	Reference
	50‐<60	52	1699	2.28	1.36‐3.81	1.8 × 10−3
	≥60	36	1050	3.62	2.08 ‐ 6.32	5.9 × 10−6
	Smoking
	Never smoker	13	1184	1.00	Reference
	Past smoker	29	1053	2.20	1.12‐4.30	2.1 × 10−2
	Current smoker	66	1812	3.14	1.71‐5.77	2.3 × 10−4
	Alcohol consumption
	Nondrinkers/<5 d per week or < 23 g of ethanol/day	43	2490	1.00	Reference
	≥5 d per week and ≥23 g of ethanol/day	65	1559	2.15	1.45‐3.20	1.5 × 10−4
Gene‐environment interaction model
	Age, y
	<50	20	1300	1.00	Reference
	50‐<60	52	1699	2.24	1.33‐3.77	2.3 × 10−3
	≥60	36	1050	3.71	2.13‐6.48	3.9 × 10−6
	Smoking
	Never smoker	13	1184	1.00	Reference
	Past smoker	29	1053	2.07	1.05‐4.08	3.5 × 10−2
	Current smoker	66	1812	2.94	1.58‐5.45	6.4 × 10−4
	Combination of alcohol consumption and ALDH2 genotype
	Nondrinkers/<5 d per week or <23 g of ethanol/day + Glu/Glu Nondrinkers/<5 d per week or <23 g of ethanol/day + Glu/Lys + Lys/Lys	43	2490	1.00	Reference
	≥5 d per week and ≥ 23 g ethanol/day + Glu/Glu	41	1351	1.58	1.02‐2.46	4.1 × 10−2
	≥5 d per week and ≥ 23 g ethanol/day + Glu/Lys + Lys/Lys	24	208	6.00	3.53‐10.19	3.4 × 10−11

Abbreviation: ALDH2, aldehyde dehydrogenase 2.