TABLE 2.
C‐index (95% confidence interval) | IDI | Continuous NRI | Categorical NRI a | |
---|---|---|---|---|
Model | ||||
Environmental model | 0.67 (0.52‐0.80) | Reference | Reference | Reference |
Gene‐environment interaction model | 0.71 (0.57‐0.84) | 0.0036 | 0.033 | 0.13 |
Abbreviations: IDI, integrated discrimination improvement; NRI, net reclassification improvement.
Risk category of NRI was defined as <0.25%, ≥0.25%, and <1% and ≥1% 10‐y absolute risk of developing upper aerodigestive tract cancer.