. 2020 Aug 4;111(10):3835–3844. doi: 10.1111/cas.14573

TABLE 3.

External validity of the developed risk prediction models based on the case‐cohort subjects from the 5‐y follow‐up survey

	C‐index (95% confidence interval)	IDI	Continuous NRI	Categorical NRI ^a
Model
Environmental model	0.72 (0.44‐0.93)	Reference	Reference	Reference
Gene‐environment interaction model	0.76 (0.50‐0.96)	0.0089	0.37	0.16

Abbreviations: IDI, integrated discrimination improvement; NRI, net reclassification improvement.

^{^a}

Risk category of NRI was defined as <0.25%, ≥0.25%, and <1%, and ≥1% 10‐y absolute risk of developing upper aerodigestive tract cancer.