FIGURE 1.

DHCR24 expression is higher in ER‐positive and HER2‐positive breast cancer. mRNA expression data from the breast cancer cohort in the TCGA database were downloaded and analyzed (A‐C). A, mRNA expression levels of DHCR24 in 1100 breast cancer tissues and 112 non‐tumor tissues. ****P < .0001. B, DHCR24 mRNA expression levels are significantly higher in luminal A, luminal B or HER2 + breast cancer compared with normal breast tissues or triple negative breast tumor tissues after analyzing data in TCGA database. **** P < .0001. C, DHCR24 mRNA expression is higher in breast tumor tissues compared with the adjacent normal breast tissues (n = 112). ****P < .0001. D, Immunoblot analysis of DHCR24 protein levels in the indicated ER+, HER2+, or triple negative breast cancer (TNBC) cell lines. The experiment was repeated 3 times