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. 2020 Aug 11;9(19):7231–7243. doi: 10.1002/cam4.3344

FIGURE 4.

FIGURE 4

MiR‐5683 dampens glycolysis through inhibition of pyruvate dehydrogenase kinase 4 (PDK4) expression in gastric cancer (GC) cells. (A, B) Glucose uptake and lactate production by BGC823 cells transfected with lentiviruses expressing miR‐5683‐mimics or miR‐5683‐mimics plus the PDK4 expression vector. (C, D) Extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) in BGC823 cells transfected as in (A) and (B). (E, F) Glucose uptake and lactate production by SGC7901 cells transfected with lentiviruses expressing miR‐5683‐inhibitor or miR‐5683‐inhibitor plus the shPDK4 vector. (G, H) ECAR and OCR in SGC7901 cells were transfected as in (E) and (F). All data are presented as the mean ± SD of quintuplicate measurements of three independent experiments. *p < .05, **p < .01, ***p < .001.