Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The mechanism of ZHX2 promoting proteasome inhibitor resistance. When bortezomib inhibits the proteasome, the degradation of ZHX2 is decreased. Accumulated ZHX2 binding to NF‐κB enhancing nuclear translocation of NF‐κB and activation of NF‐κB target genes expression, which can attenuate the antitumor activity of proteasome inhibitor
