Table 1.
Demographics and Perioperative Characteristics of the HTx Recipients Stratified by eGFR
| Overall (n = 95) |
eGFR (ml/min/1.73 m2) | P value | |||
|---|---|---|---|---|---|
| < 30 (n = 25) | 30–59 (n = 61) | ≥60 (n = 9) | |||
| Demographic data | |||||
| Age, years | 54.31 ± 11.92 | 58.88 ± 9.75 | 55.15 ± 9.20 | 35.89 ± 17.20 | 0.0007* |
| Sex, men, n (%) | 81(85.26) | 19(76.00) | 54(88.52) | 8(88.89) | 0.318 |
| BMI (kg/m2) | 24.54 ± 3.83 | 23.89 ± 3.15 | 24.70 ± 4.08 | 25.25 ± 3.92 | 0.575 |
| History of alcohol | 29(30.53) | 10(40.00) | 17(27.87) | 2(22.22) | 0.464 |
| History of smoking | 63(66.32) | 16(64.00) | 41(67.21) | 6(66.67) | 0.960 |
| Hypertension | 39(41.05) | 15(60.00) | 21(34.43) | 3(33.33) | 0.083 |
| Diabetes mellitus | 34(35.79) | 12(48.00) | 19(31.15) | 3(33.33) | 0.334 |
| Chronic kidney disease | 20(21.05) | 12(48.00) | 6(9.84) | 2(22.22) | 0.0005* |
| Pretransplant characteristics | |||||
| DCM | 38(40.00) | 7(28.00) | 26(42.62) | 5(55.56) | 0.279 |
| CAD | 27(28.42) | 9(36.00) | 16(26.23) | 2(22.22) | 0.604 |
| Valve disease | 15(15.79) | 3(12.00) | 10(16.39) | 2(22.22) | 0.756 |
| Pre-PCI | 11(11.58) | 4(16) | 7(11.48) | 0(0) | 0.441 |
| ICD implantation | 3(3.16) | 2(8.00) | 1(1.64) | 0(0) | 0.267 |
| LVAD implantation | 1(1.05) | 0(0) | 0(0) | 1(11.11) | 0.008* |
| Cardiac tumor | 1(1.05) | 0(0) | 1(1.64) | 0(0) | 0.755 |
| EF pre-HTx (%) | 28(23,31) | 30(24,33) | 26(23,30) | 25(20,30) | 0.257 |
| Creatinine (mg/dL) | 1.14(0.95,1.27) | 1.60(1.33,1.91) | 1.10(0.95,1.22) | 0.76(0.70,0.87) | <.0001* |
| Intraoperative characteristics | |||||
| CPB duration (min) | 225(183,262) | 225(180,270) | 220(193,255) | 210(180,225) | 0.822 |
| Blood transfusion (ml) | 1440(1100,2100) | 1400(1100,2000) | 1440(1100,2200) | 1640(1000,2050) | 0.849 |
| Infusion (ml) | 1810(1320,2440) | 2000(1505,2580) | 1800(1320,2350) | 1700(1190,1925) | 0.483 |
| Blood loss (ml) | 1000(1000,2200) | 1500(1000,2500) | 1000(1000,2000) | 1500(1000,2000) | 0.804 |
| Urine volume (ml) | 1800(1200,2500) | 1300(770,1650) | 2000(1300,2500) | 2150(2000,2900) | 0.001* |
| IABP/ECMO | 6(6.32) | 4(16.00) | 2(3.28) | 0(0) | 0.065 |
| Postoperative characteristics | |||||
| AKI stage | |||||
| NO-AKI | 62(65.26) | 16(64.00) | 40(65.57) | 6(66.67) | 0.428 |
| Stage 1 | 9(9.47) | 0(0) | 8(13.11) | 1(11.11) | |
| Stage 2 | 8(8.42) | 2(8.00) | 4(6.56) | 2(22.22) | |
| Stage 3 | 16(16.84) | 7(28.00) | 9(14.75) | 0(0) | |
| Urine volume | |||||
| 1st Day after operation | 2200(1980,2805) | 2100(1965,2485) | 2200(1980,2735) | 2525(2115,3320) | 0.194 |
| 2nd Day after operation | 2125(1765,2505) | 1935(1400,2498) | 2135(1845,2500) | 2425(2005,2970) | 0.081 |
| 3rd Day after operation | 2110(1860,2050) | 2050(1400,2498) | 2145(1930,2450) | 2305(2050,2440) | 0.300 |
| Mechanical ventilation (min) | 1080(840,2220) | 1920(960,3720) | 1040(783,2100) | 960(720,1410) | 0.134 |
| RRT | 16(16.84) | 7(28.00) | 9(14.75) | 0(0) | 0.123 |
| Time from operation to discharge (days) | 26(22,33) | 29(23,37) | 26(22,32) | 24(20,26) | 0.370 |
| Death | 15(15.79) | 4(16.00) | 10(16.39) | 1(11.11) | 0.921 |
| Mortality in hospital | 11(11.58) | 4(16.00) | 6(9.84) | 1(11.11) | 0.719 |
| Death within 1 year | 3(3.16) | 0(0) | 3(4.92) | 0(0) | 0.422 |
| Follow-up days | 608(303,1180) | 555(341,951) | 692(276,1180) | 1451(497,2132) | 0.199 |
* P < 0.05; eGFR was calculated using the Chronic Kidney Disease Epidemiology collaboration equation. HTx Heart transplantation, eGFR Estimated glomerular filtration rate, BMI Body mass index, DCM Dilated cardiomyopathy, CAD Coronary arterial disease, Pre-PCI Previous percutaneous coronary intervention, ICD Implantable cardioverter defibrillator, LVAD Left ventricular assist device, CPB Cardiopulmonary bypass, RRT Renal replacement therapy. Numbers in brackets are interquartile ranges (IQRs). ANOVA was applied to the BMI variable because of its normal distribution. The Kruskal-Wallis test was used to compare other variables