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. 2020 Oct 6;19:167. doi: 10.1186/s12933-020-01142-0

Table 3.

Spearman correlation analysis between PCSK9 and cardiovascular metabolic makers

Variables Overall DM Non-DM
n = 1225 n = 377 n = 848
r p r p r p
Traditional lipid parameters
 TC 0.199  < 0.0001 0.133 0.010 0.234  < 0.0001
 TG 0.063 0.028 0.010 0.851 0.078 0.023
 HDL-C 0.096 0.001 0.098 0.057 0.100 0.003
 LDL-C 0.195  < 0.0001 0.153 0.003 0.215  < 0.0001
Novel lipid markers
 non-HDL-C 0.180  < 0.0001 0.104 0.043 0.217  < 0.0001
 Lp(a) 0.062  < 0.0001 0.079 0.126 0.054 0.117
 ApoA1 0.092 0.001 0.104 0.044 0.090 0.009
 ApoB 0.192  < 0.0001 0.138 0.007 0.213  < 0.0001
 TRLP 0.045 0.116 0.046 0.371 0.038 0.264
Derived lipid indicators
 TG/HDL-C 0.012 0.682 −0.032 0.538 0.023 0.510
 LDL-C/HDL-C 0.073 0.010 0.026 0.620 0.089 0.009
 TC/HDL-C 0.037 0.195 −0.019 0.712 0.056 0.102
 ApoB/ApoA1 0.075 0.009 0.034 0.510 0.088 0.011
 non-HDL-C/TC 0.037 0.195 −0.019 0.712 0.056 0.102
 AIP 0.012 0.682 −0.032 0.538 0.023 0.510
 LCI 0.112  < 0.0001 0.042 0.414 0.139  < 0.0001
Other metabolic indexes
 SBP −0.014 0.632 −0.001 0.988 −0.033 0.343
 DBP −0.039 0.169 −0.059 0.252 −0.035 0.315
 BMI −0.007 0.815 −0.042 0.417 −0.008 0.818
 Glucose 0.104  < 0.0001 0.088 0.087 0.087 0.012
 HbA1C 0.123  < 0.0001 0.111 0.032 0.098 0.004
 HGI 0.112  < 0.0001 0.076 0.141 0.085 0.013
 TyG 0.088 0.002 0.040 0.435 0.087 0.011

PCSK9 proprotein convertase subtilisin/kexin type 9, CAD coronary artery disease, DM diabetes mellitus, non-DM non-diabetes mellitus, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, non-HDL-C non-high-density lipoprotein cholesterol, ApoA1 Apolipoprotein A1, ApoB apolipoprotein B, TRLP triglyceride-rich lipoproteins, AIP atherogenic index of plasma, LCI lipoprotein combine index, SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, HbA1C hemoglobin A1C, HGI hemoglobin glycation index, TyG triglyceride glucose, p < 0.05 suggests significant difference. (TRLP = TC—HDL-C—LDL-C; LCI = TC ∗ TG ∗ LDL/HDL-C; AIP = log (TG/HDL-C); TyG = Ln (TG*FPG/2); HGI = observed HbA1c—predicted HbA1c), p < 0.05 suggests significant difference