Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 29;9(9):bio053405. doi: 10.1242/bio.053405

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Fig. 7. — Cell to cell communication mediate GB progression in Drosophila. Glioma cells produce a network of TMs that grow to reach the surrounding tissue that includes neurons. Grnd is increased in the GB TMs and Egr is produced in the surrounding tissue. Egr activates the JNK signalling pathway through Grnd in GB. As a consequence, MMPs are upregulated in GB and facilitate further TM infiltration in the brain that is necessary for synapse loss in the surrounding neurons and GB cell number increase. This results in tumour progression and lethality.