Table 3.
Crude and age-adjusted incidence rates of brain/CNS tumors by sex, according to histology group, for Georgia, March 1, 2009 to February 29, 2012
| Group | Specific histology | WHO histology code | N | % | CIR | AIR (95% CI) | Females | Males | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | % | CIR | AIR (95% CI) | N | % | CIR | AIR (95% CI) | |||||||
| Neuroepithelial tumors | 180 | 12.2 | 1.35 | 1.30 (1.12, 1.51) | 94 | 11.7 | 1.35 | 1.24 (0.99, 1.52) | 84 | 14.3 | 1.33 | 1.34 (1.07, 1.67) | ||
| Pilocytic astrocytoma | 9421 | 11 | 0.7 | 0.08 | 0.10 (0.05, 0.17) | 5 | 0.6 | 0.07 | 0.08 (0.03, 0.18) | 6 | 1.0 | 0.09 | 0.11 (0.04, 0.25) | |
| Diffuse astrocytoma | 9400, 9411, 9420 | 15 | 1.0 | 0.11 | 0.10 (0.06, 0.17) | 7 | 0.9 | 0.10 | 0.10 (0.04, 0.20) | 8 | 1.4 | 0.13 | 0.12 (0.05, 0.24) | |
| Anaplastic astrocytoma | 9401 | 21 | 1.4 | 0.16 | 0.15 (0.09, 0.23) | 11 | 1.4 | 0.16 | 0.15 (0.07, 0.27) | 10 | 1.7 | 0.16 | 0.15 (0.07, 0.28) | |
| Glioblastoma | 9440, 9441, 9442/3 | 72 | 4.9 | 0.54 | 0.50 (0.39, 0.63) | 35 | 4.4 | 0.50 | 0.42 (0.29, 0.59) | 37 | 6.3 | 0.59 | 0.59 (0.42, 0.82) | |
| Other astrocytomas | 9380, 9381, 9384, 9424, 9425 | 2 | 0.1 | 0.02 | 0.01 (0.00, 0.05) | 1 | 0.1 | 0.01 | 0.01 (0.00, 0.08) | 1 | 0.2 | 0.02 | 0.02 (0.00, 0.10) | |
| Oligodendroglioma | 9450 | 9 | 0.6 | 0.07 | 0.06 (0.03, 0.12) | 5 | 0.6 | 0.07 | 0.06 (0.02, 0.14) | 4 | 0.7 | 0.06 | 0.06 (0.02, 0.17) | |
| Anaplastic oligodendroglioma | 9451 | 5 | 0.3 | 0.04 | 0.04 (0.01, 0.09) | 2 | 0.2 | 0.03 | 0.03 (0.00, 0.11) | 3 | 0.5 | 0.05 | 0.05 (0.01, 0.14) | |
| Oligoastrocytoma | 9382 | 21 | 1.4 | 0.16 | 0.15 (0.09, 0.24) | 13 | 1.6 | 0.19 | 0.18 (0.09, 0.31) | 8 | 1.4 | 0.13 | 0.12 (0.05, 0.25) | |
| Ependymoma | 9383, 9391, 9392, 9394 | 8 | 0.5 | 0.06 | 0.06 (0.02, 0.12) | 7 | 0.9 | 0.10 | 0.09 (0.04, 0.19) | 1 | 0.2 | 0.02 | 0.02 (0.00, 0.11) | |
| Neuronal—glial | 8680, 9390, 9413, 9492, 9493, 9505, 9506 | 9 | 0.6 | 0.07 | 0.06 (0.03, 0.12) | 6 | 0.7 | 0.09 | 0.08 (0.03, 0.18) | 1 | 0.2 | 0.02 | 0.01 (0.00, 0.09) | |
| Embryonal—medulloblastoma | 9470, 9471, 9473, 9508 | 7 | 0.5 | 0.05 | 0.06 (0.03, 0.13) | 2 | 0.2 | 0.03 | 0.03 (0.00, 0.12) | 5 | 0.9 | 0.08 | 0.09 (0.03, 0.21) | |
| Tumors of cranial and spinal nerves | Neurinoma | 9560 | 45 | 3.0 | 0.34 | 0.33 (0.24, 0.44) | 30 | 3.7 | 0.43 | 0.39 (0.26, 0.56) | 14 | 2.4 | 0.22 | 0.24 (0.13, 0.40) |
| Tumors of meninges | 410 | 27.8 | 3.05 | 2.81 (2.54, 3.10) | 262 | 32.6 | 3.70 | 3.23 (2.84, 3.66) | 125 | 21.3 | 1.96 | 1.92 (1.60, 2.30) | ||
| Meningioma | 9530, 9531, 9532, 9533, 9534, 9537, 9538, 9539 | 374 | 25.3 | 2.78 | 2.56 (2.30, 2.84) | 243 | 30.3 | 3.43 | 2.97 (2.60, 3.39) | 110 | 18.7 | 1.73 | 1.70 (1.39, 2.05) | |
| Mesenchymal—lipoma, haemangioma | 8815, 8850, 8861, 9120, 9133, 9150, 9180, 9220, 9364 | 25 | 1.7 | 0.19 | 0.18 (0.11, 0.26) | 14 | 1.7 | 0.20 | 0.19 (0.10, 0.32) | 10 | 1.7 | 0.16 | 0.15 (0.07, 0.28) | |
| Haemangioblastoma | 9161 | 11 | 0.7 | 0.08 | 0.08 (0.04, 0.14) | 5 | 0.6 | 0.07 | 0.07 (0.02, 0.16) | 5 | 0.9 | 0.08 | 0.08 (0.02, 0.19) | |
| Lymphomas | Lymphoma | 9590, 9680 | 5 | 0.3 | 0.04 | 0.04 (0.01, 0.09) | 3 | 0.4 | 0.04 | 0.04 (0.01, 0.12) | 2 | 0.3 | 0.03 | 0.03 (0.00, 0.13) |
| Germ cell | Germinoma | 9064, 9080, 9084 | 4 | 0.3 | 0.03 | 0.03 (0.01, 0.07) | 1 | 0.1 | 0.01 | 0.01 (0.00, 0.08) | 3 | 0.5 | 0.05 | 0.05 (0.01, 0.15) |
| Tumors of the sellar region | 211 | 14.3 | 1.58 | 1.52 (1.32, 1.75) | 125 | 15.6 | 1.79 | 1.73 (1.44, 2.06) | 69 | 11.7 | 1.08 | 1.05 (0.82, 1.34) | ||
| Pituitary adenoma | 8271, 8272 | 192 | 13.0 | 1.44 | 1.38 (1.19, 1.59) | 115 | 14.3 | 1.65 | 1.57 (1.30, 1.89) | 61 | 10.4 | 0.95 | 0.93 (0.71, 1.21) | |
| Craniopharyngioma | 9350 | 19 | 1.3 | 0.14 | 0.14 (0.09, 0.22) | 10 | 1.2 | 0.14 | 0.15 (0.07, 0.28) | 8 | 1.4 | 0.13 | 0.12 (0.05, 0.24) | |
| Unclassified | Unclassified | 8000 | 621 | 42.3 | 4.66 | 4.45 (4.10, 4.82) | 288 | 35.9 | 4.12 | 3.83 (3.39, 4.31) | 291 | 49.5 | 4.59 | 4.56 (4.05, 5.13) |
| Total | 1476 | 100 | 11.05 | 10.48 (9.94, 11.04) | 803 | 100 | 11.44 | 10.47 (9.75, 11.24) | 588 | 100 | 9.26 | 9.20 (8.47, 9.99) | ||
Age unknown: N = 8
Sex unknown: N = 85
AIR age-adjusted incidence rate per 100,000 person-years (adjusted to the US 2000 standard population), 95% CI 95% confidence intervals (based on the gamma distribution proposed by Tiwari et al. [17]), CIR crude incidence rate