Table 4.
Crude and age-adjusted incidence rates of brain/CNS tumors by sex, according to histology group, for Zurich (Switzerland), March 1, 2009 to February 29, 2012
| Group | Specific histology | WHO histology code | N | % | CIR | AIR (95% CI) | Females | Males | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | % | CIR | AIR (95% CI) | N | % | CIR | AIR (95% CI) | |||||||
| Neuroepithelial | 377 | 34.1 | 9.23 | 8.37 (7.52, 9.29) | 148 | 23.3 | 7.16 | 6.49 (5.45, 7.68) | 229 | 48.7 | 11.35 | 10.57 (9.22, 12.07) | ||
| Pilocytic astrocytoma | 9421 | 13 | 1.2 | 0.32 | 0.43 (0.23, 0.73) | 4 | 0.6 | 0.19 | 0.27 (0.07, 0.66) | 9 | 1.9 | 0.45 | 0.59 (0.27, 1.10) | |
| Diffuse astrocytoma | 9400, 9411, 9420 | 17 | 1.5 | 0.42 | 0.37 (0.21, 0.60) | 7 | 1.1 | 0.34 | 0.34 (0.13, 0.71) | 10 | 2.1 | 0.50 | 0.42 (0.20, 0.79) | |
| Anaplastic astrocytoma | 9401 | 25 | 2.3 | 0.61 | 0.58 (0.37, 0.86) | 10 | 1.6 | 0.48 | 0.47 (0.22, 0.87) | 15 | 3.2 | 0.74 | 0.70 (0.39, 1.17) | |
| Glioblastoma | 9440, 9441, 9442/3 | 216 | 19.6 | 5.29 | 4.32 (3.76, 4.95) | 83 | 13.1 | 4.02 | 3.20 (2.53, 3.99) | 133 | 28.3 | 6.59 | 5.69 (4.76, 6.77) | |
| Other astrocytomas | 9380, 9381, 9384, 9424, 9425 | 19 | 1.7 | 0.47 | 0.44 (0.26, 0.70) | 10 | 1.6 | 0.48 | 0.50 (0.22, 0.94) | 9 | 1.9 | 0.45 | 0.42 (0.19, 0.81) | |
| Oligodendroglioma | 9450 | 5 | 0.5 | 0.12 | 0.11 (0.03, 0.26) | 2 | 0.3 | 0.10 | 0.09 (0.01, 0.34) | 3 | 0.6 | 0.15 | 0.12 (0.02, 0.39) | |
| Anaplastic oligodendroglioma | 9451 | 7 | 0.6 | 0.17 | 0.15 (0.06, 0.31) | 3 | 0.5 | 0.15 | 0.13 (0.03, 0.40) | 4 | 0.9 | 0.20 | 0.17 (0.05, 0.46) | |
| Oligoastrocytoma | 9382 | 9 | 0.8 | 0.22 | 0.20 (0.09, 0.38) | 4 | 0.6 | 0.19 | 0.17 (0.05, 0.45) | 5 | 1.1 | 0.25 | 0.22 (0.07, 0.53) | |
| Ependymoma | 9383, 9391, 9392, 9394 | 39 | 3.5 | 0.95 | 0.96 (0.68, 1.32) | 12 | 1.9 | 0.58 | 0.63 (0.32, 1.11) | 27 | 5.7 | 1.34 | 1.31 (0.86, 1.92) | |
| Neuronal—glial | 8680, 9390, 9413, 9492, 9493, 9505, 9506 | 14 | 1.3 | 0.34 | 0.40 (0.21, 0.67) | 7 | 1.1 | 0.34 | 0.32 (0.13, 0.68) | 7 | 1.5 | 0.35 | 0.46 (0.18, 0.92) | |
| Embryonal—medulloblastoma | 9470, 9471, 9473, 9508 | 13 | 1.2 | 0.32 | 0.42 (0.22, 0.72) | 6 | 0.9 | 0.29 | 0.38 (0.13, 0.81) | 7 | 1.5 | 0.35 | 0.46 (0.19, 0.93) | |
| Tumours of cranial and spinal nerves | Neurinoma | 9560 | 118 | 10.7 | 2.89 | 2.50 (2.06, 3.00) | 61 | 9.6 | 2.95 | 2.51 (1.91, 3.24) | 57 | 12.1 | 2.82 | 2.45 (1.85, 3.19) |
| Tumours of meninges | 449 | 40.7 | 10.99 | 9.04 (8.22, 9.93) | 346 | 54.6 | 16.75 | 13.02 (11.66, 14.51) | 103 | 21.9 | 5.10 | 4.45 (3.63, 5.42) | ||
| Meningioma | 9530, 9531, 9532, 9533, 9534, 9537, 9538, 9539 | 435 | 39.4 | 10.65 | 8.71 (7.90, 9.58) | 340 | 53.6 | 16.46 | 12.72 (11.38, 14.19) | 95 | 20.2 | 4.71 | 4.06 (3.28, 4.98) | |
| Mesenchymal—lipoma, haemangioma | 8815, 8850, 8861, 9120, 9133, 9150, 9180, 9220, 9364 | 3 | 0.3 | 0.07 | 0.07 (0.01, 0.21) | 2 | 0.3 | 0.10 | 0.10 (0.01, 0.36) | 1 | 0.2 | 0.05 | 0.05 (0.00, 0.27) | |
| Haemangioblastoma | 9161 | 11 | 1.0 | 0.27 | 0.26 (0.13, 0.48) | 4 | 0.6 | 0.19 | 0.20 (0.05, 0.52) | 7 | 1.5 | 0.35 | 0.34 (0.14, 0.72) | |
| Lymphomas | Lymphoma | 9590, 9680 | 18 | 1.6 | 0.44 | 0.37 (0.22, 0.59) | 7 | 1.1 | 0.34 | 0.31 (0.12, 0.65) | 11 | 2.3 | 0.55 | 0.49 (0.24, 0.89) |
| Germ cell | Germinoma | 9064, 9080, 9084, | 5 | 0.5 | 0.12 | 0.13 (0.04, 0.31) | 1 | 0.2 | 0.05 | 0.04 (0.00, 0.26) | 4 | 0.9 | 0.20 | 0.22 (0.06, 0.55) |
| Tumours of the sellar region | 92 | 8.3 | 2.25 | 1.92 (1.54, 2.36) | 44 | 6.9 | 2.13 | 1.80 (1.30, 2.44) | 48 | 10.2 | 2.38 | 2.11 (1.55, 2.81) | ||
| Pituitary adenoma | 8271, 8272 | 92 | 8.3 | 2.25 | 1.92 (1.54, 2.36) | 44 | 6.9 | 2.13 | 1.80 (1.30, 2.44) | 48 | 10.2 | 2.38 | 2.11 (1.55, 2.81) | |
| Craniopharyngioma | 9350 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Unclassified | Unclassified | 8000 | 45 | 4.1 | 1.10 | 0.96 (0.69, 1.30) | 27 | 4.3 | 1.31 | 1.10 (0.70, 1.64) | 18 | 3.8 | 0.89 | 0.83 (0.49, 1.33) |
| Total | 1104 | 100 | 27.03 | 23.29 (21.91, 24.73) | 634 | 100 | 30.69 | 25.27 (23.29, 27.39) | 470 | 100 | 23.29 | 21.12 (19.22, 23.16) | ||
AIR age-adjusted incidence rate per 100,000 person-years (adjusted to the US 2000 standard population), 95% CI 95% confidence intervals (based on the gamma distribution proposed by Tiwari et al. [17]), CIR crude incidence rate