Table 1.

Network and functional analyses of differentially expressed genes found only in the AD mouse blood

Top canonical pathways
Name		P value	Overlap
1	3-phosphoinositide degradation	1.12E-03	6.2% 9/146
2	Primary immunodeficiency signaling	3.18E-03	11.4% 4/35
3	D-myo-inositol-5-phosphate metabolism	4.49E-03	5.4% 8/147
4	Superpathway of inositol phosphate compounds	6.11E-03	4.8% 9/188
5	3-Phosphoinositide biosynthesis	6.38E-03	5.1% 8/156
Top upstream regulators
Name		P value	Predicted activation
1	IL3	3.85E-07
2	IL21	1.38E-05	Inhibited
3	IL15RA	1.69E-05
4	IFNA2	4.21E-05	Inhibited
5	TLN1	5.55E-05
Causal network
Name		P value	Predicted activation
1	MAP3K13	4.93E-07	Inhibited
2	Interferon beta-1a	5.66E-07
3	TLR7	6.02E-07	Inhibited
4	KAT7	7.48E-07	Activated
5	Androgen-AR	2.10E-06	Inhibited
Top diseases and bio functions
Diseases and disorders
Name		P value range	Number of molecules
1	Cancer	9.16E-03–5.36E-06	287
2	Hematological disease	8.80E-03–5.36E-06	106
3	Immunological disease	8.80E-03–5.36E-06	131
4	Organismal injury and abnormalities	9.27E-03–5.36E-06	291
5	Inflammatory response	6.92E-03–2.02E-05	46
Molecular and cellular functions
Name		P value range	Number of molecules
1	Cellular development	9.27E-03–5.57E-07	111
2	Cellular growth and proliferation	9.27E-03–5.57E-07	113
3	Cell death and survival	9.18E-03–4.80E-06	117
4	Cell cycle	9.18E-03–4.80E-06	63
5	Cell-to-cell signaling and interaction	9.27E-03–2.02E-05	59
Physiological system development and function
Name		P value range	Number of molecules
1	Hematological system development and function	9.27E-03–4.13E-08	84
2	Hematopoiesis	9.27E-03–4.13E-08	54
3	Tissue development	9.27E-03–5.57E-07	75
4	Embryonic development	9.27E-03–6.04E-06	57
5	Lymphoid tissue structure and development	9.27E-03–6.04E-06	60