Table 3.

Genes that showed significant changes in expression with age and that exhibited correlations between the blood and hippocampus only in AD mice (C12, control mice at 12 w.o.a.; C52, control mice at 52 w.o.a.; AD12, AD mice at 12 w.o.a.; AD52, AD mice at 52 w.o.a.; bld, blood; hip, hippocampus; FC, fold change; w.o.a., weeks of age). The significantly altered genes (two-way ANOVA: P < 0.1, fold change ≥ 1.5 or ≤ − 1.5, Tukey’s HSD: P < 0.05) are indicated in italics

Gene symbol	p (Mouse-Age)	p (Mouse)	p (Age)	C12 bld vs. C52 bld		C12 bld vs. AD12 bld		C12 bld vs. AD52 bld		C52 bld vs. AD12 bld		C52 bld vs. AD52 bld		AD12 bld vs. AD52 bld
				p	FC	p	FC	p	FC	p	FC	p	FC		FC
Cdkn2a	0.0570	0.1532	0.1590	0.9809	− 1.1766	0.9830	− 1.1691	0.1906	2.4127	1.0000	1.0064	0.0922	2.8389	0.0950	2.8208
Apobec3	0.1030	0.7599	0.0970	1.0000	1.0041	0.7655	− 1.1946	0.4907	1.2990	0.7531	− 1.1995	0.5039	1.2937	0.0993	1.5518
Magi2	0.7870	0.2662	0.0849	0.7101	1.4178	0.9284	1.2198	0.1893	1.9613	0.9669	− 1.1623	0.7535	1.3834	0.4766	1.6079
Parp3	0.0421	0.8478	0.0578	0.9996	− 1.0200	0.5284	− 1.2876	0.4306	1.3279	0.5940	− 1.2624	0.3720	1.3544	0.0339	1.7098
Cass4	0.0971	0.0001	0.0012	0.5507	1.1953	0.2224	1.3022	0.0002	2.1544	0.9182	1.0895	0.0009	1.8023	0.0043	1.6544
Gene symbol	p (Mouse-Age)	p (Mouse)	p (Age)	C12 Hip vs. C52 Hip		C12 Hip vs. AD12 Hip		C12 Hip vs. AD52 Hip		C52 Hip vs. AD12 Hip		C52 Hip vs. AD52 Hip		AD12 Hip vs. AD52 Hip
				P	FC	p	FC	p	FC	p	FC	p	FC	p	FC
Cdkn2a	0.0544	0.0111	0.0000	0.1687	1.7901	0.0120	− 2.4951	0.3816	1.5594	0.0002	− 4.4663	0.9574	− 1.1479	0.0003	3.8909
Apobec3	0.0156	0.5956	0.0136	1.0000	1.0089	0.4852	− 1.3705	0.1370	1.6324	0.4615	− 1.3827	0.1479	1.6181	0.0052	2.2373
Magi2	0.2062	0.0802	0.0467	0.9441	1.1186	0.1484	− 1.5570	0.9976	1.0386	0.0475	− 1.7416	0.9826	− 1.0770	0.1031	1.6170
Parp3	0.0694	0.4886	0.0026	0.7494	1.1354	0.2804	− 1.2612	0.2761	1.2628	0.0398	− 1.4320	0.8355	1.1122	0.0053	1.5927
Cass4	0.0414	0.7084	0.0023	0.8262	1.1739	0.3046	− 1.3943	0.1772	1.4813	0.0614	− 1.6368	0.6049	1.2618	0.0032	2.0654