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. 2020 Jun 19;21(6):709–719. doi: 10.1007/s10522-020-09887-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Longevity effects of geroprotectors relate to maximum likelihoods of causing side effects. a Top 10 highest and lowest ranked geroprotectors in relation to the total number of side effects they are predicted to produce. b Top 10 highest and lowest ranked geroprotectors in relation to the maximum probability of a side effect. c Positive correlation observed in worms (C. elegans) between geroprotector’s lifespan extension and probability of causing a side effect (R = 0.32, p = 0.0018)