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. Author manuscript; available in PMC: 2020 Oct 27.
Published in final edited form as: Nat Biotechnol. 2020 Apr 27;38(10):1194–1202. doi: 10.1038/s41587-020-0505-4

Figure 4. Antigen discovery for TCR specificity group III.

Figure 4.

a, Antigen screen for TCR124 as described in figure 3. b, Individual protein from the positive subpool (PL2F) were expressed separately and screened against TCR124. PL2-F6 (Rv1388) showed positive activation. c, Overlapping peptides spanning protein mIHF (Rv1388) were screened against TCR124. Insert table lists identified peptide antigen. Mean ± s.d. (n=2, biological replicates) shown. d, Dose-dependent response of Group III TCR123-TCR125 to its peptide antigen. Mean ± s.d. (n=3, biological replicates) shown. EC50 values were determined as described in figure 3.