Table 1.

Targeting chromatin modulators showing a role in maintaining genome integrity and function of hematopoietic cells

Protein	Molecular function	DNA damage	DDR, repair	ROS	Possible mechanism		Refs
					Direct	Indirect
TET2&3	DNA hydroxylation & demethylation		DDR↑ Repair ↓ in mature cells		Accumulate at damage sites	Regulating repair gene expression	[111]
KMT2A/MLL1	H3K4 methylation and more				S-phase checkpoint execution		[121]
KMT2D/MLL4	H3K4 methylation (and more?)	↑	DDR↑	↑	Relieving transcription stress; Promoting replication fork degradation	Regulating redox gene expression and ROS	[126, 129, 135]
KMT2E/MLL5	Organizing chromatin	↑	DDR↑ Repair ↓	↑			[134]
KMT2F/SET1A	H3K4 methylation and more	↑	DDR↑ Repair ↓	↓	Protecting replication fork degradation	Regulating repair gene expression	[136–138]
DPY30	H3K4 methylation (and more?)	↑	DDR↑ Repair ↓	↓		Regulating repair gene expression	[101]
BMI1		↑	DDR↑	↑		Metabolically increased ROS	[89]
MYSM1	H2A deubiquitination		DDR↑	↑			[145]
SETD2	H3K36 methylation	↑	DDR↑ Repair ↓		Facilitating repair		[149, 150]
SIRT1	Deacetylation of histones and other proteins	↑	DDR↑	↑		Regulating redox gene expression	[67, 68]