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Ferrostatin-1 (FS-1), a ferroptosis inhibitor, or vehicle alone (Veh) was administered i.p. for 2 weeks post-irradiation (IR). Coronary artery endothelial cell density was assessed by counting intimal nuclei and normalizing to 100 um luminal perimeter (n=7). While FS-1 treatment appeared to partially rescue EC loss compared to non-irradiated (NI) controls, vehicle-treated mice were not significantly different from FS-1 treated mice (P=0.23).
