Table 3.
Genotype and allele frequencies of HOTAIR SNPs in cases and controls, and genotype- and allelotype-specific risks.
| Locus | Model | Genotype | Patients | Controls | Odds Ratio | p-value |
|---|---|---|---|---|---|---|
| rs17720428 | ||||||
| Allele | T | 359 (59.8%) | 393 (65.5%) | 1 | 0.04 | |
| G | 241 (40.21%) | 207 (34.5%) | 1.27 (1.01–1.61) | |||
| Codominant | TT | 102 (34%) | 131 (43.7%) | 1 | 0.05 | |
| TG | 155 (51.7%) | 131 (43.7%) | 1.52 (1.07–2.15) | |||
| GG | 43 (14.3%) | 38 (12.6%) | 1.45 (0.87–2.41) | |||
| Dominant | TT | 102 (34%) | 131 (43.7%) | 1 | 0.01 | |
| TG + GG | 198 (66%) | 169 (56.3%) | 1. 5 (1.08–2.1) | |||
| Recessive | TT + TG | 257 (85.7%) | 262 (87.4%) | 1 | 0.55 | |
| GG | 43 (14.3%) | 38 (12.6%) | 1.15 (0.72–1.84) | |||
| Overdominant | TT + GG | 145 (48.3%) | 169 (56.3%) | 1 | 0.05 | |
| TG | 155 (51.7%) | 131 (43.7%) | 1.38 (1–1.9) | |||
| Log-Additive | 1.28 (1.01–1.63) | 0.04 | ||||
| rs7958904 | ||||||
| Allele | G | 315 (52.7%) | 355 (59.4%) | 1 | 0.02 | |
| C | 283 (47.3%) | 243 (40.6%) | 1.31 (1.04–1.65) | |||
| Codominant | GG | 80 (26.8%) | 109 (36.5%) | 1 | 0.04 | |
| GC | 155 (51.8%) | 137 (45.8%) | 1.54 (1.07–2.22) | |||
| CC | 64 (21.4%) | 53 (17.7%) | 1.64 (1.03–2.62) | |||
| Dominant | GG | 80 (26.8%) | 109 (36.5%) | 1 | 0.01 | |
| GC + CC | 219 (73.2%) | 190 (63.5%) | 1.57 (1.1–2.22) | |||
| Recessive | GG + GC | 235 (78.6%) | 246 (82.3%) | 1 | 0.26 | |
| CC | 64 (21.4%) | 53 (17.7%) | 1.26 (0.84–1.9) | |||
| Overdominant | GG + CC | 144 (48.2%) | 162 (54.2%) | 1 | 0.14 | |
| GC | 155 (51.8%) | 137 (45.8%) | 1.27 (0.92–1.75) | |||
| Log-Additive | 1.31 (1.04–1.65) | 0.02 | ||||
| rs1899663 | ||||||
| Allele | G | 358 (59.9%) | 393 (65.5%) | 1 | 0.04 | |
| T | 240 (40.1%) | 207 (34.5%) | 1.27 (1.01–1.61) | |||
| Codominant | GG | 102 (34.1%) | 131 (43.7%) | 1 | 0.06 | |
| GT | 154 (51.5%) | 131 (43.7%) | 1.51 (1.06–2.13) | |||
| TT | 43 (14.4%) | 38 (12.7%) | 1.45 (0.87–2.41) | |||
| Dominant | GG | 102 (34.1%) | 131 (43.7%) | 1 | 0.02 | |
| GT + TT | 197 (65.9%) | 169 (56.3%) | 1.5 (1.08–2.08) | |||
| Recessive | GG + GT | 256 (85.6%) | 262 (87.3%) | 1 | 0.54 | |
| TT | 43 (14.4%) | 38 (12.7%) | 1.16 (0.72–1.85) | |||
| Overdominant | GG + TT | 145 (48.5%) | 169 (56.3%) | 1 | 0.05 | |
| GT | 154 (51.5%) | 131 (43.7%) | 1.37 (0.99–1.89) | |||
| Log-Additive | 1.28 (1.01–1.62) | 0.04 | ||||
| rs4759314 | ||||||
| Allele | A | 586 (97.7%) | 590 (98.3%) | 1 | 0.41 | |
| G | 14 (2.3%) | 10 (1.7%) | 1.41 (0.62–3.2) | |||
| Codominant | AA | 286 (95.3%) | 290 (96.7%) | 1 | 0.4 | |
| AG | 14 (4.7%) | 10 (3.3%) | 1.42 (0.62–3.25) | |||
| GG | – | – | – | |||
| Dominant | – | – | – | – | ||
| – | – | – | – | |||
| Recessive | – | – | – | – | ||
| – | – | – | – | |||
| Overdominant | – | – | – | – | ||
| – | – | – | – | |||
OR, odds ratio; CI, confidence interval; SNPs, single nucleotide polymorphisms.