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. 2020 Oct 7;10:16714. doi: 10.1038/s41598-020-73698-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Phase contrast images of RA-induced differentiation of SH-SY5Y cells after (a) 0 (Control), (b) 3, (c) 6 and (d) 9 days. Scale bar = 50 µm. (e) Changes in gene expression during 3, 6 and 9 days of differentiation of the SH-SY5Y cells. Principal component analysis plot of rlog transformed count data for the RNA-sequencing samples of 4 individual experiments (N = 4). Each replicate clusters according to their individual differentiation status. (f) Venn diagram showing overlap of differentially expressed genes between the different time points of differentiation of SH-SY5Y cells. Genes with FDR-adjusted p-value ≤ 0.05 and an absolute log2(fold change) > 1 were regarded as differentially expressed. Unprocessed phase contrast images are represented in Supplementary Figure S6.