Table 1.

The enriched canonical pathways identified by DEGs after 9 days of differentiation. The selection was based on the significant pathways part of the ‘Neurotransmitters and other nervous system signalling’ and ‘Ingenuity toxicity pathways’ categories according to the IPA software.

Ingenuity canonical pathways	−log(p-value)	z-score
Axonal guidance signalling	8.24	NA
Hepatic fibrosis/hepatic stellate cell activation	5.29	NA
Synaptic long term depression	4.09	3.62
Cell cycle: G1/S checkpoint regulation	3.99	0.94
p53 Signalling	3.92	0.58
Cell cycle: G2/M DNA damage checkpoint regulation	3.85	1.00
Neuropathic pain signalling in dorsal horn neurons	3.72	3.41
GABA receptor signalling	3.51	NA
Dopamine-DARPP32 feedback in cAMP signalling	3.43	2.47
GPCR-mediated nutrient sensing in enteroendocrine cells	3.35	4.02
CREB signalling in neurons	3.07	2.96
CDK5 signalling	3.00	2.29
Aryl hydrocarbon receptor signalling	2.69	-1.40
Reelin signalling in neurons	2.66	NA
Opioid signalling pathway	2.50	3.39
Circadian rhythm signalling	2.20	NA
Glutamate receptor signalling	2.01	0.33
Agrin interactions at neuromuscular junction	1.98	3.15
Netrin signalling	1.98	NA
GNRH signalling	1.90	3.00
Parkinson's signalling	1.84	NA
RAR activation	1.45	NA
ErbB2-ErbB3 signalling	1.40	1.60
Gustation pathway	1.39	NA
NRF2-mediated oxidative stress response	1.38	1.00
Synaptic long term potentiation	1.38	2.60

z-score is a measure of the predicted activation state of the pathway. Z-score > 0 pathway predicted to be activated; z-score < 0 pathway predicted to be inhibited. NA- activity pattern not available.