Table 1.
Comparison among three TB tests (mIGRA, TST, and TB culture) in 39 cynomolgus monkeys (A) Agreement between the mIGRA and the TST, (B) Agreement between TB culture and the mIGRA and between TB culture and the TST.
| TST | mIGRA | |||||
|---|---|---|---|---|---|---|
| Negative | Positive | Total | ||||
| Negative | 23 | 6 | 29 | |||
| Positive | 2 | 8 | 10 | |||
| Total | 25 | 14 | 39 | |||
| Cohen’s kappa coefficient (κ) value | 0.524 | Moderate agreement | ||||
| p-value | 0.0003 | |||||
| 95% Confidence interval (CI) | 0.2434–0.8053 | |||||
| TB culture | mIGRA | TST | ||||
|---|---|---|---|---|---|---|
| Negative | Positive | Total | Negative | Positive | Total | |
| Negative | 24 | 7 | 31 | 26 | 5 | 31 |
| Positive | 1 | 7 | 8 | 3 | 5 | 8 |
| Total | 25 | 14 | 39 | 29 | 10 | 39 |
| Cohen's kappa coefficient (κ) value | 0.508 | Moderate agreement | 0.424 | Moderate agreement | ||
| p-value | 0.0004 | 0.0120 | ||||
| 95% Confidence interval (CI) | 0.2290–0.7868 | 0.0932–0.7555 | ||||
Cohen's kappa coefficient (κ) values, p-values and 95% confidence intervals (CIs) were calculated by Rstudio Version 1.3.1073 at https://www.rstudio.com (vcd package). The κ-value in the range of 0.41–0.6 means moderate agreement26. The italics indicate a total number of monkey cases found positive or negative. Bold is used for topics only such as Kappa value, p-value and CIs.