Table 1.
Study Characteristics.
| First Author | Year | n CUD (HC) | Mean Age CUD (HC) | n M/F (HC) | Grouping Medical Comorbidity | Lifetime Drug Use History | Min. Abstinence Time (Days) | Mean Years of Use | Brand | Direction |
|---|---|---|---|---|---|---|---|---|---|---|
| Bell* | 2011 | 43 (43) | 37.4 (38.8) | 41/2 (36/7) | NONE | CUD: ANY HC: NONE | 7 | 9.3 | Siemens | 8 |
| Kelly | 2011 | 25 (24) | 35.0 (35.1) | 23/2 (20/4) | NONE | CUD: A/C HC: NONE | 14 | 11.4 | Siemens | 64 |
| Lane | 2010 | 15 (18) | 38.5 (35.2) | 10/5 (9/9) | NONE | CUD: ANY HC: NONE | 1 | 10.1 | Phillips | 21 |
| Lim‡ | 2008 | 21 (21) | 42.5 (40.9) | 11/10 11/10 | NONE | CUD: NONE HC: NONE | 4 | 18.9 | Siemens | 12 |
| van Son | 2016 | 37 (38) | 29.5 (31.1) | 37/0 38/0 | NONE | CUD: ANY HC: NONE | 15 | 4.1 | Phillips | 32 |
| Vaquero | 2017 | 30 (30) | 32.9 (32.3) | 24/6 24/6 | NONE | CUD: NO O HC: NO O | 1 | 12.9 | Siemens | 12 |
| Wakim | 2017 | 15 (21) | 50.3 (36.3) | 0/15 (0/21) | CUD: HIV+ HC: NONE | CUD: ANY HC: NONE | 60 | 11.9 | Phillips | 32 |
| Yip | 2017 | 38 (38) | 42.5 (38.1) | 25/13 28/10 | NONE | CUD: ANY HC: NONE | N/I | N/I | Siemens | 32 |
Notes. HC: Controls; CUD: Cocaine Use Disorder; M/F: Male/Female; ABS: Abstinent; CUR: Current Users; N/I: No Information; Drug Use: A: Alcohol; C: Cannabis; H: Heroin; O: Opiates
*
denotes studies that used a 1.5T MRI (rather than 3T);
†
indicates simultaneous use of any substance except nicotine;
‡
denotes studies that were previously included in an ROI-based meta-analysis.