Table 3.

Studies linking VOC exposure with risk of common NHL subtypes

NHL Subtype	Author	Casesa	Controlsb	Genetic Predisposition	Exposure	Exposure Assessment	Exposure Metric	Effect Estimate (95% CI)
DLBCL	Deng et al.37, †	160	717	IL10 polymorphism	Occupational exposure to organic solvents	Self-report; job-exposure matrix	Ever exposed	OR=3.31 (1.80-6.08)
	Jiao et al.38, †	518	597	MGMT polymorphism	Occupational exposure to chlorinated solvents	Self-report; job-exposure matrix	Ever exposed	OR=4.24 (2.03-8.86)
	De Roos et al.39	1321	1057	--	Residence near chemicals and allied products facility	Residence	10 years lived within 2 miles of a facility	OR=1.9 (1.2-2.9)
	Bulka et al.40	3851	N/A	--	Residence near Toxic Release Inventory site (formaldehyde)	Residence	Distance near site 10 years prior to diagnosis	β = −0.0058 (p<0.001)
	Switchenko et al.41	NR	N/A	--	Residence near Toxic Release Inventory site (benzene)	Residence	Distance near site 10 years prior to diagnosis	RR=1.66 (1.46-1.88)
FL	Jiao et al.38, †	518	597	MGMT polymorphism	Occupational exposure chlorinated solvents	Self-report; job-exposure matrix	Ever exposed	OR=4.44 (1.86-10.61)
	Cocco et al.36	4279	3788	--	Occupational exposure to trichloroethylene	Self-report; industrial hygienists; job exposure matrix	Frequency of work time > 31%	OR=1.8 (1.1-2.9)
	Cocco et al.63	2348	2462	--	Occupational exposure to benzene, toluene, xylene (combined)	Self-report; industrial hygienists	Ever exposed	OR=1.7 (1.2-2.5)
					Styrene	Self-report; industrial hygienists	Ever exposed	OR=2.6 (1.3-5.2)
CLL/SLL	Cocco et al.63	367	2179	--	Occupational exposure to organic solvents	Self-report; industrial hygienists	Ever exposed	OR=1.5 (1.1.−1.9)

^aTotal exposed/unexposed cases

^bTotal exposed/unexposed controls

^†Overlapping cohorts

Abbreviations: NHL = non-Hodgkin lymphoma; DLBCL = diffuse large B-cell lymphoma; FL = follicular lymphoma; VOC = volatile organic compounds; OR = odds ratio; CI = confidence interval.