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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Nanoscale. 2020 Oct 1;12(37):19088–19092. doi: 10.1039/d0nr05008c

Figure 3.

Figure 3.

Effect of 1 on cell viability in HS578T spheroids: (a) Normalized LDH release as a function of time and concentration of 1; (b-e) Cell death shown by microscopy images after (b, d) live/dead (projection of the whole spheroid) and (c, e) hematoxylin/eosin staining. LDH release of HS578T spheroids as a function of (f) ALP inhibition (I), (g) GLUT1 and (h) CAV1 knockdown (KD). The applied treatment (Treat.) was spheroid exposition to 1 (1 mM, 48 h). Statistics: ns (non-significant); * p < 0.01; ** p < 0.005; *** p < 0.001; **** p < 0.0001.