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. Author manuscript; available in PMC: 2021 Mar 14.
Published in final edited form as: Nat Methods. 2020 Sep 14;17(10):1025–1032. doi: 10.1038/s41592-020-0934-5

Figure 2.

Figure 2.

Analysis of synTac specificity in vitro. Splenocytes from C57BL/6 mice treated with VHHCD11b-E7 (shortened as VHH-E7) plus adjuvant or from IAV-infected mice were incubated overnight with HPV E749–57 (RAHYNIVTF), HPV E7 synTac, IAV NP366–374 (ASNENMETM), or IAV NP synTac (100 nM equivalent). The number of IFN-γ-secreting cells was measured via ELISpot assay. Shown are means ± SD of an experiment performed in quadruplicate (biological replicates and is representative of two independent experiments (****p < 0.0001; two-sided Student’s t-test).