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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Cancer Res. 2020 Jul 2;80(19):4046–4057. doi: 10.1158/0008-5472.CAN-19-4032

Figure 1: Microarray analysis reveals a family of Y chromosome, radiation inducible long non-coding RNAs.

Figure 1:

(A) Y chromosome schematic obtained from the UCSC Genome Browser demonstrating the genomic location of the three linc-SPRY3 transcripts in the DYZ1 region (also known as lnc-BPY2C). (B) Linc-SPRY3 transcripts sequences. Highlighted sections indicate pentanucleotide repeats. The black underline regions show the sequences target by the shRNAs and siRNAs used in this study (C) qRT-PCR analysis of the linc-SPRY3 family members validating the radiation induced expression in H460 cells. Time course expression following a single dose of 8Gy IR of linc-SPRY3-2/3/4. GAPDH mRNA was used to normalize qRT-PCR analysis. Error bars represent SD from the mean (n=3).