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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Oncogene. 2020 Aug 25;39(40):6286–6299. doi: 10.1038/s41388-020-01434-5

Figure 5.

Figure 5.

Dysregulation of ephrin receptor signaling genes with DICER1 deletion. QPCR showed upregulation of ephrin receptor signaling genes in human DICER1−/− cells (A) and dcKO mice (B). QPCR showed upregulation of hedgehog signaling genes in dcKO uteri (C). Mean± SEM; 2-tailed Student’s t-test; ***, P < 0.001; n = 6; RQ, relative quantity of each gene transcript relative to endogenous control gene GAPHD (human) and 18S (mouse) normalized to DICER1+/+ (A) or Pten cKO (B-C). (D) Elevated Ki67 expression in dcKO compared Pten cKO. (Scale bars, 50 μm.) Mean± SEM; 2-tailed Student’s t-test; ***, P < 0.001; n > 8.