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. 2020 Apr 7;10(2):131–143. doi: 10.1002/cpdd.795

Figure 4.

Figure 4

Plasma cytokine levels following endotoxin challenge and MW189 administration. Healthy adult male volunteers were administered a single intravenous dose of MW189 (0.25 mg/kg) or matched placebo, followed immediately by a single intravenous injection of low‐dose endotoxin (LPS, 2 ng/kg) to induce increases in plasma cytokine levels. Blood was collected over a 12‐hour period after the LPS challenge, and plasma cytokines were measured by ELISA (8 MW189, 8 placebo). Mean ± SEM plasma levels (pg/mL) are shown for (A) IL‐10 and (B) TNF‐α. Note that MW189 treatment increases the anti‐inflammatory cytokine IL‐10 level and decreases the proinflammatory cytokine TNF‐α level compared with placebo treatment. The inset graph in (B) shows an expansion of the data for the last 4 times (4, 6, 8, and 12 hours). *Statistically significant difference between MW189 and placebo groups.