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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Cell. 2020 Sep 24;183(1):28–45. doi: 10.1016/j.cell.2020.09.014

Figure 5. Genome function drives structure.

Figure 5.

All cells of an organism contain genomes of identical sequence (left single nucleus), but different cell-types express distinct gene expression programs (heatmaps) and consequently have different genome topologies as detected by chromatin interaction maps. The cell-type specific homotypic chromatin-chromatin interactions drive higher-order genome organization and generate distinct overall genome topologies in different cell types, resulting in cell-type specific patterns of euchromatin (green) and heterochromatin (red). (right) Within a cell type, the heterogeneity of chromatin-chromatin interactions generates cell-to-cell variability in the population.