Table 2.
The associations of sentinel variants representing each locus and overall survival of all lung cancer and adenocarcinoma
| European ancestry | Japanese ancestry | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Location | Lead SNP | Gene¥ | Effect | Ref | MAF | HR* (95% CI) | P | I2 | P(HET) | MAF | HR* (95% CI) | P |
| Lung cancer | ||||||||||||
| 1p22.3 | rs2911600 | LINC01461 | T | C | 0.033 | 2.02(1.53,2.66) | 6.41E-07 | 36.2 | 0.180 | 0.066 | 0.88 (0.64,1.21) | 0.438 |
| 8q23.3 | rs7822185 | LINC00536 | A | G | 0.035 | 2.71(1.83,4.00) | 6.45E-07 | 49.7 | 0.113 | 0.063 | 1.05 (0.77,1.45) | 0.729 |
| 9q31.3 | rs4978466 | Intergenic | A | G | 0.292 | 0.76(0.69,0.85) | 4.78E-07 | 38.6 | 0.164 | 0.083 | 0.99 (0.74,1.32) | 0.976 |
| 10p14 | rs17143938 | Intergenic | T | C | 0.058 | 0.58(0.47,0.72) | 5.99E-07 | 0 | 0.714 | n/a | n/a | n/a |
| Adenocarcinoma | ||||||||||||
| 1p36.13 | rs214346 | CAPZB | A | G | 0.424 | 0.72(0.63,0.82) | 5.86E-07 | 29.5 | 0.225 | 0.366 | 1.01 (0.85,1.19) | 0.900 |
| 4p14 | rs17603438 | NWD2/KIAA1239 | A | G | 0.100 | 0.50(0.38,0.66) | 6.92E-07 | 0 | 0.588 | 0.452 | 0.79 (0.67,0.94) | 0.007 |
| 5q11.2 | rs10041935 | Intergenic | A | C | 0.267 | 0.73(0.65,0.83) | 6.84E-07 | 38.2 | 0.152 | 0.275 | 0.89 (0.75,1.06) | 0.199 |
| 7p21.3 | rs10247578 | Intergenic | A | G | 0.403 | 1.38(1.23,1.55) | 7.69E-08 | 32.7 | 0.191 | 0.203 | 0.88 (0.72,1.09) | 0.258 |
| 9q34.3 | rs6569 | UBAC1 | A | C | 0.481 | 0.72(0.63,0.82) | 5.94E-07 | 0 | 0.991 | 0.489 | 1.00 (0.87,1.16) | 0.922 |
| 10p15.3 | rs17158233 | Intergenic | A | G | 0.024 | 3.68(2.23,6.09) | 3.66E-07 | 0 | 0.628 | 0.090 | 1.22 (0.96,1.56) | 0.100 |
| 11q14.1 | rs17148028 | DLG2 | T | G | 0.061 | 0.48(0.36,0.64) | 5.66E-07 | 0 | 0.968 | 0.125 | 1.26 (0.97,1.65) | 0.081 |
| 13q22.2 | rs12875562 | Intergenic | T | C | 0.122 | 1.71(1.41,2.07) | 3.60E-08 | 0 | 0.959 | 0.112 | 1.11(0.87,1.42) | 0.372 |
*
Hazard ratios (HRs) are from a meta-analysis of Cox-PH models adjusted by age, sex, clinical stage, principal components and when available by treatment. Ref: reference allele; Effect: the allele being evaluated; MAF : Minor allele frequency of the single nucleotide polymorphism; P : P-value; I2 : the I-squared statistic described the percentage of variation across studies that is due to heterogeneity; P(HET): the p-value for heterogeneity.
¥
Host or closest gene