Table 3:
Expression quantitative trait loci (eQTL) identified in both Lung MicroArray project and GTEx database
| Lung MicroArray eQTL | GTEx eQTL for lung tissue d | |||||
|---|---|---|---|---|---|---|
| Location | Lead SNP | Genea | Target Geneb | P-valuec | Target Geneb | P-value |
| 1p36.13 | rs214346 | CAPZB | CAPZB | 2.78 × 10−10 | CAPZB | 1.10 × 10−9 |
| 9q34.3 | rs6569 | UBAC1 | UBAC1 | 1.14 × 10−3 | UBAC1 | 9.20 × 10−14 |
| 13q22.2 | rs12875562 | Intergenic | LMO7DN | 0.003 | LMO7DN | 9.40 × 10−7 |
a
based on variant location
b
gene with the most significant eQTL association within a 1 Mb up and downstream of the transcription probe set.
c
eQTL P-value is based on meta-analysis of Laval University, University of British Columbia, University of Groningen studies.
d
Genotype-Tissue Expression (GTEx) database (http://www.gtexportal.org/home/) of RNAseq analysis in 515 lung human tissues (Release V7)
CAPZB, Capping Actin Protein Of Muscle Z-Line Subunit Beta; UBAC1, UBA Domain Containing 1; LMO7DN, LIM Domain 7 Downstream Neighbour