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. Author manuscript; available in PMC: 2021 Oct 28.
Published in final edited form as: Cancer Lett. 2020 Jul 28;491:70–77. doi: 10.1016/j.canlet.2020.07.025

Figure 5. Inhibition of JNK ameliorates muscle wasting in tumor-bearing mouse model.

Figure 5.

(A) IHC staining for c-Jun and H&E in methacarn-fixed muscle sections from female athymic nude mice; experiemental groups included tumor-bearing (TB) mice orthotopically implanted with S2–013 pancreatic cancer cells, TB mice treated with 10 mg/kg SP600125 (TB + SP600125), or unimplanted healthy control (HC) mice (scale bar = 100 μm). (B) Quantification of c-Jun staining and (C) muscle fiber cross-sectional area. The mRNA expression of (D) Trim63 and (E) Fbxo32 from flash frozen mouse gastrocnemius muscle. Data are represented as mean ± SEM. Data were compared by one-way ANOVA followed by Tukey’s post hoc test. *p < 0.05 and **p < 0.01.