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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Transplantation. 2020 Aug;104(8):1580–1590. doi: 10.1097/TP.0000000000003263

Figure 6: Lymphocyte Reconstitution:

Figure 6:

(A) Total lymphocytes counts. Peripheral lymphocyte numbers reached a nadir by day 10, but recovered soon after. (B) Absolute numbers of peripheral CD8 T cells. CD8 T cell numbers increased rapidly after the transplant and accounted for the majority of circulating lymphocytes. (C) Ratio of circulating CD8 to CD4 T cells. CD8/4 ratios of the three surviving animals revealed a shift in the normal ratio where CD4 T cells are more abundant to where CD8 cells predominate. (D) Absolute numbers of circulating CD8 T-effector memory cells. The vast majority of CD8 cells were effector memory T cells defined as CD95+/CD28- CD8 T cells. (E) Absolute numbers of circulating CD4/CD25hi/FoxP3+ Tregs/microliter in peripheral blood. Blue lines show results for GA704C, Red lines show results for N770L, and Green lines show results for SA110B.