Skip to main content
. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Mech Ageing Dev. 2020 Aug 17;191:111334. doi: 10.1016/j.mad.2020.111334

Figure 1.

Figure 1.

Mitochondrial DNA mutation and dynamics have a broad effect in stem cell aging. (A) mtDNA mutations that accumulate as stem cell age may partially contribute to dysfunctional stem/progenitor cells. (B) The mitochondrial fission/fusion balance go to the side of fusion as stem cell aged, leading to increased ROS mediated by NRF2 as well as altered Mfn2/Ca2+/Nfat signal cascade. (C) Mitochondrial quality is less controlled due to decreased mitophagy in old stem cells, leading to decreased stem cell maintenance, increased ROS levels and potential immune activation.