Table 1.
Baseline demographic and laboratory parameters of the groups
| Variable | Group 1 (13 patients) anti-factor Xa < 0.2 IU/mL | Group 2 (67 patients) Anti-factor Xa > 0.2 IU/mL | p value |
|---|---|---|---|
| Age (year) | 43.77 ± 16.77 | 45.15 ± 15.93 | 0.77 |
| Gender, n (%) | |||
| Male | 7 (53.8) | 33(49.3) | 0.76 |
| Female | 6 (46.2) | 34 (50.7) | |
| BMI (kg/m2) | 27.96 ± 4.25 | 26.26 ± 4.40 | 0.20 |
| GFR (mL/min) | 104.55 ± 26.94 | 103.13 ± 20.36 | 0.84 |
| Hypertension, n (%) | 4 (30.8) | 8 (11.9) | 0.09 |
| Diabetes mellitus, n (%) | 2 (15.4) | 7 (10.4) | 0.60 |
| Coronary artery disease, n (%) | 1 (7.7) | – | 0.16 |
| Medication, n (%) | |||
| Chloroquine | 13 (100) | 67 (100) | 1 |
| Azitromisin | 10 (76.9) | 53 (79.1) | 0.86 |
| Osetlemivir | 4 (30.8) | 6 (9.0) | 0.06 |
| Favipiravir | 3 (23.1) | 15 (22.4) | 0.95 |
| LMWH, n (%) | |||
| Single dose | 11 (84.6) | 49 (73.1) | 0.38 |
| Double dose | 2 (15.4) | 18 (26.9) | |
| CT finding, n (%) | |||
| Positive | 8 (61.5) | 43 (64.2) | 0.85 |
| Negative | 5 (38.5) | 24 (35.8) | |
| SpO2 | 97.38 ± 1.80 | 96.96 ± 2.10 | 0.49 |
| QT interval (ms) | 385.92 ± 13.00 | 390.17 ± 31.41 | 0.64 |
| WBC × 103/mL | 5.91 ± 1.31 | 5.54 ± 1.89 | 0.51 |
| Neutrophil | 3.57 ± 1.27 | 3.51 ± 1.71 | 0.91 |
| Lymphocyte | 1.76 ± 0.60 | 1.54 ± 0.66 | 0.25 |
| Eosinophil (%) | 2.96 ± 2.55 | 0.90 ± 1.28 | 0.001 |
| Eosinophil (%) | |||
| > 4 (%) | 6 (46.2) | 8 (11.9) | 0.009 |
| < 4 (%) | 7 (53.8) | 59 (88.1) | |
| Eosinophil count | 168.42 ± 147.25 | 50.32 ± 73.42 | 0.001 |
| RBC × 106/mL | 4.91 ± 0.37 | 5.15 ± 4.27 | 0.84 |
| Hemoglobin (gr/dl) | 13.86 ± 1.93 | 13.30 ± 2.30 | 0.42 |
| Platelet × 103/mL | 232.00 ± 62.21 | 197.57 ± 57.87 | 0.06 |
| Sedimentation (%) | 30.00 ± 22.86 | 32.46 ± 23.28 | 0.72 |
| CRP (mg/L) | 12.18 ± 16.66 | 25.12 ± 31.04 | 0.08 |
| Procalcitonin (μgr/L) | 0.11 ± 0.08 | 0.13 ± 0.19 | 0.60 |
| Fibrinogen (mg/dl) | 367.08 ± 134.97 | 410.00 ± 117.34 | 0.24 |
| Iron (μg/dl) | 55.92 ± 39.59 | 44.82 ± 23.48 | 0.76 |
| TIBC (μg/dl) | 264.54 ± 97.22 | 281.62 ± 75.30 | 0.47 |
| Ferritin (ng/mL) | 166.85 ± 130.83 | 220.06 ± 212.54 | 0.38 |
| Transferrin saturation (%) | 19.10 ± 14.49 | 15.06 ± 9.45 | 0.75 |
| D-dimer (μgr/mL) | 0.57 ± 0.38 | 1.21 ± 3.35 | 0.50 |
| Glucose (mg/dl) | 112.77 ± 42.29 | 106.82 ± 37.29 | 0.60 |
| BUN (mg/dl) | 12.62 ± 6.50 | 12.83 ± 4.95 | 0.89 |
| Creatinine (mg/dl) | 0.83 ± 0.39 | 0.78 ± 0.20 | 0.49 |
| AST (U/L) | 26.00 ± 9.53 | 29.69 ± 17.61 | 0.46 |
| ALT (U/L) | 25.00 ± 15.43 | 26.18 ± 18.59 | 0.83 |
| LDH (U/L) | 258.31 ± 110.76 | 252.37 ± 89.03 | 0.83 |
| Sodium (mmol/L) | 139.77 ± 3.03 | 137.15 ± 15.74 | 0.55 |
| Potassium (mEq/L) | 4.14 ± 0.49 | 4.07 ± 0.40 | 0.58 |
| Calcium (mg/dl) | 8.76 ± 0.49 | 8.46 ± 0.52 | 0.11 |
| Magnesium (mg/dl) | 1.91 ± 0.19 | 2.03 ± 0.21 | 0.07 |
| CK (U/L) | 140.77 ± 95.69 | 145.67 ± 184.75 | 0.92 |
| CK-MB (ng/mL) | 1.17 ± 0.79 | 1.11 ± 0.61 | 0.78 |
| Tn I (pg/mL) | 23.12 ± 60.26 | 5.33 ± 5.48 | 0.06 |
| BNP (pg/mL) | 60.67 ± 63.28 | 91.43 ± 129.54 | 0.40 |
| LDL (mg/dl) | 74.38 ± 20.56 | 81.55 ± 24.98 | 0.33 |
| HDL (mg/dl) | 37.46 ± 13.01 | 37.71 ± 11.39 | 0.94 |
| Triglyceride (mg/dl) | 119.23 ± 70.37 | 131.80 ± 66.85 | 0.54 |
| Total protein (g/L) | 6.72 ± 0.45 | 6.92 ± 0.47 | 0.15 |
| Albumin (g/L) | 3.96 ± 0.44 | 3.97 ± 0.33 | 0.87 |
| PT | 11.55 ± 0.91 | 11.82 ± 1.92 | 0.62 |
| aPTT (s) | 23.25 ± 3.24 | 25.62 ± 8.45 | 0.32 |
| INR | 0.95 ± 0.06 | 0.96 ± 0.19 | 0.89 |
| Baseline anti-factor Xa level (IU/mL) | 0.18 ± 0.06 | 0.43 ± 0.23 | < 0.001 |
ALT alanin aminotransferase, aPTT activated partial thromboplastin time, AST aspartate aminotransferase, BMI body mass index, BNP brain natriuretic peptide, BUN blood urea nitrogen, CAD coronary artery disease, CK creatine kinase, CK-MB creatine kinase-myocardial band, CRP C-reactive protein, CT computerized tomography, DM diabetes mellitus, GFR glomerular filtration rate, HDL high density lipoprotein, HT hypertension, INR international normalized ratio, LDH lactate dehydrogenase, LDL low density lipoprotein, LMWH low molecular weight heparin, PT prothrombin time, RBC red blood cell, SpO2, oxygen saturation, TG triglyceride, TIBC total iron binding capacity, Tn I troponin I, WBC white blood cell
Parameters that p < 0.05 are written in italics