Skip to main content
. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Mol Cell. 2020 Aug 19;80(1):59–71.e4. doi: 10.1016/j.molcel.2020.08.001

Figure 2. Molecular recognition of Gs by β1-AR.

Figure 2.

(A-D) Different views of the interaction surface areas between β1-AR (in magenta) and the Ras-like GTPase domain of Gαs (in green) are shown. (E-H) Comparison of the conformations of β1-AR in the active state (magenta) as seen in the β1-AR–Gs complex and with that of β1-AR in the inactive state (PDB: 4GPO) (cyan). (E) The overall alignment of the inactive β1-AR and the active β1-AR. (F) Major conformational changes in TM5, TM6 and TM7. (G and H) Conformational changes in the conserved D(E)RY motif on TM3 (G) and the conserved NPxxY motif on TM7 (H).