Table 2:
Summary table presenting associations between microbiome composition and colorectal (number of studies=50) and oral cancer risk (n=16)
| Taxa & diversity | Colorectal cancer | N (%) studies for that finding* | Oral cancer | N (%) studies for that finding* | |
|---|---|---|---|---|---|
| PHYLUM | Bacteroidetes | S & T | 3 (19) | ||
| Firmicutes | S | 2 (13) | |||
| Fusobacteria | F & T | 10 (20) | S & T | 2 (13) | |
| FAMILY | Fusobacteriaceae | F & T | 2 (4) | ||
| Lachnospiraceae | F & T | 6 (12) | |||
| Peptostreptococcaceae | F | 2 (4) | |||
| Porphyromonadaceae | F | 2 (4) | |||
| Ruminococcaceae | F &T | 5 (10) | |||
| GENUS | Actinomyces | S | 2 (13) | ||
| Acinetobacter | F | 3 (6) | |||
| Atopobium | F & T | 4 (8) | |||
| Bifidobacterium | F & T | 4 (8) | |||
| Blautia | F & T | 2 (4) | |||
| Capnocytophaga | S & T | 2 (13) | |||
| Desulfovibrio | F | 2 (4) | |||
| Dialister | S & T | 2 (13) | |||
| Fusobacterium | F & T | 16 (32) | S & T | 4 (25) | |
| Gemella | F & T | 3 (6) | |||
| Leptotrichia | F & T & S | 3 (6) | |||
| Odoribacter | F | 2 (4) | |||
| Oscillibacter | F | 2 (4) | |||
| Parvimonas | F | 6 (12) | S & T | 2 (13) | |
| Peptostreptococcus | F & T | 5 (10) | S & T | 2 (13) | |
| Porphyromonas | F & T | 8 (16) | |||
| Prevotella | F | 2 (4) | |||
| Staphylococcus | F | 2 (7) | |||
| Streptococcus | S | 4 (25) | |||
| SPECIES | Bacteroides fragilis | F & T | 4 (8) | ||
| Blautia coccoides | F | 2 (4) | |||
| Escherichia coli | F & T | 2 (4) | |||
| Fusobacterium nucleatum | F & T | 11 (22) | |||
| Parvimonas micra | F | 4 (8) | |||
| Peptostreptococcus stomatis | F | 3 (6) | |||
| Porphyromonas assaccharolytica | F | 2 (4) | |||
| Prevotella intermedia | F & S | 2 (4) | |||
| DIVERSITY | Beta diversity | Sign. in 7 studies | 7 (14) | ||
|
Strong positive association (≥3 publications in same direction; none in opposite direction) |
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|
Suggestive positive association (2 publications in same direction; none in opposite direction) |
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|
Strong negative association (≥3 publications in same direction; none in opposite direction) |
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|
Suggestive negative association (2 publications in same direction; none in opposite direction) |
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Abbreviations: F= faecal samples, S= saliva samples, T= tissue samples (cancer site specific)
*
Example n (%): 10 and 2 studies for Fusobacteria for CRC & oral cancer respectively, so 20% and 13% of the total number of studies on CRC & oral cancer