Skip to main content
. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Clin Cancer Res. 2020 Jul 27;26(19):5246–5257. doi: 10.1158/1078-0432.CCR-19-3102

Figure 6. Effect of low-dose AT13387 treatment on radiosensitivity in vivo.

Figure 6.

The effect of treatment on UMSCC74B (top panel), SCCVII (middle panel), and MiaPCa2 (bottom panel) tumors is shown. Mice bearing 100 mm3 or larger tumors were treated with AT13387, Radiation, or a combination as described in methods. Tumor volume was measured three times per week, and weight was recorded daily. Shown here are the tumor volumes as a function of time (A, D, and G), median times to second tumor doubling (TD2) along with log-rank p-values after initiation of treatment (B, E, and H) and the effect of treatment on mouse body weight (C, F, and I). Control: purple; AT13387/AT: Blue; Radiation/RT: Red; AT+RT: Green.