Table 1.

Body and liver masses, liver/body mass ratio and biochemical parameters

Parameters	Group
	3–4 weeks		9–10 weeks
	Normal diet	CDHFD	Normal diet	CDHFD
Body weight (g)	299.1 ± 20.5	206.2 ± 15.7**	433.3 ± 16.2	246.0 ± 11.9**
Liver weight (g)	9.9 ± 0.8	13.9 ± 2.1**	12.1 ± 12	18.8 ± 2.9**
Liver/body weight ratio	0.033 ± 0.001	0.067 ± 0.007**	0.028 ± 0.002	0.076 ± 0.008**
AST (IU/L)	74.9 ± 12.6	564 ± 438	62.7 ± 16.6	566 ± 229**
ALT (IU/L)	45.1 ± 13.1	760 ± 528*	38.6 ± 15.9	229 ± 94.6*
TC (mg/dL)	56.4 ± 4.4	31.4 ± 3.1	51.7 ± 10.4	66.6 ± 23.7
TG (mg/dL)	96.2 ± 33.4	4.6 ± 3.2**	184 ± 131	8.1 ± 4.6*
GLU (mg/dL)	192 ± 20.1	143 ± 13.8**	201 ± 18.1	127 ± 16.6**
TBA (mg/dL)	7.6 ± 4.6	117 ± 91.3	13.2 ± 12.2	138 ± 75.1*
ALB (g/dL)	2.2 ± 0.1	2.3 ± 0.1	2.3 ± 0.1	2.1 ± 0.2*
ALP (IU/L)	518 ± 75.7	1109 ± 427*	316 ± 69.7	1757 ± 818*
T-BIL (mg/dL)	0.11 ± 0.02	0.44 ± 0.24*	0.09 ± 0.02	0.66 ± 0.41*

Values are expressed as means ± SDs (n = 5). *P < 0.05, **P < 0.01, compared with the respective normal diet-fed group

CDHFD choline-deficient, low-methionine high-fat diet, AST aspartate aminotransferase, ALT alanine aminotransferase, TC total cholesterol, TG triglyceride, GLU glucose, TBA total bile acids, ALB albumin, ALP alkaline phosphatase, T-BIL total bilirubin