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. 2020 Sep 24;11:588079. doi: 10.3389/fimmu.2020.588079

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Copyright © 2020 Chen, Zhang, Zhang, Zhang, Guo and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential metabolites and metabolic pathways. (A) Differential metabolites were identified based on P < 0.05 and VIP > 1 as the filter for control and AOM/DSS group, AOM/DSS and AOM/DSS + BBR group. (B,C) The change of differential metabolites in control and AOM/DSS group, AOM/DSS and AOM/DSS + BBR group. (D,E) Meaningful metabolic pathways in the comparison of control and AOM/DSS group, AOM/DSS and AOM/DSS + BBR group. 3-HP, 3-hydroxyphenylacetate; 3-M-2-O, 3-methyl-2-oxoisovalerate. (Control group: n = 9; AOM/DSS group: n = 7; AOM/DSS+BBR group: n = 8). *P < 0.05, **P < 0.01; ***P < 0.001.