Table 2.

Types of NOTCH1 Mutations in All Studied CLL Cases

Case No	domain	Type of mutation	Nucleotide change	Amino acid change
1;50;51;55	HD-N exon 26	Point mutation	c.*4766C>T	S1590F
3;60;70	Pest exon 34	Deletion	c.7486 del A	N2497T
4;20;22	Pest exon 34	Insertion	c. 7526_7527 ins C	E2516L H2508A
5;8;65	Pest exon 34	Point mutation	c.*550C>T	P2518L
6;74;72	Pest exon 34	Insertion	c. 7542_7483 insT	S2517F
10;23;27	Pest exon 34	Insertion	c. 7542_7483 insG	E2516G S2517V
11;54;61	Tad exon 34	Deletion	c.6821 del C	T2285A
15;44;71	HD-N exon 26	Point mutation	c.*4916A>C	E1636A
16;90;92	HD-N exon 26	Deletion	4609 Del A	C1537L K1538Q
18;73;104	HD-N exon 26	Point mutation	c.*5011G>A	V1672I
20;61;69	HD-C exon 27	Point mutation	c.*5027T>A	V1677D
25;44;77	Pest exon 34	Insertion	c. 7543_7544 ins A	S2517v
28, 30;66	Pest exon 34	Insertion	c. 7481_7482 insG	DEL DNT2496 INS GQH
29;57;88	Pest exon 34	Deletion	c.7486 del A	N2497T T2498P
		Insertion	c. 7489_7490 insC
33;101	Pest exon 34	Point mutation	c. *7513C>G	Del peh2506 ins AGA

Del, deletion; ins, insertion