Table 1.
Differential Analysis of Expression Level of the Viral Factors between Breast, Thyroid Cancer and Healthy Control Groups
| Virus | Expressed gene | Breast Cancer (N=83) | Thyroid Cancer (N=57) | Healthy Breast (N=31) | Healthy Thyroid (N=18) | Fold Change* | Fold Change$ | Adj. P-value* | Adj. P-value$ |
|---|---|---|---|---|---|---|---|---|---|
| EBV† | LMP-1 | 12.36 ± 5.23 | 14.65 ± 6.78 | 2.39 ± 5.77 | 11.50 ±7.67 | 5.17 | 1.27 | <0.001 | 0.1 |
| LMP-2A | 10.55 ± 6.60 | 14.07 ± 6.19 | 2.48 ± 5.99 | 10.90 ± 7.58 | 4.25 | 1.29 | <0.001 | 0.077 | |
| EBER 1 | 14.02 ± 4.49 | 16.22 ± 6.05 | 2.74 ± 1.16 | 10.70 ± 6.89 | 5.11 | 1.52 | <0.001 | 0.001 | |
| EBER 2 | 12.60 ± 6.83 | 15.27 ± 5.73 | 2.68 ± 1.12 | 11.0 ± 6.76 | 4.7 | 1.39 | <0.001 | 0.01 | |
| HPV‡ | L1 | 0.29 ± 0.99 | NA § | 0.1 ± 0.25 | NA | 2.9 | NA | 0.19 | NA |
| E2 | 0.79 ± 0.852 | NA | 0.48 ± 0.91 | NA | 1.62 | NA | 0.998 | NA | |
| E6 | 4.90 ± 6.77 | NA | 1.03 ± 2.66 | NA | 4.74 | NA | <0.001 | NA | |
| E7 | 3.69 ± 5.18 | NA | 1.09 ± 3.07 | NA | 3.38 | NA | 0.002 | NA |
†, Epstein-Barr virus; ‡, Human papilloma virus; § NA, Not applicable; Geometric Mean± Standard Deviation; * Adj. p-values were corrected by Benjamini-Hochberg method for multiple comparisons. Bolded P-values indicated as statistical significant at level of 0.05. * Comparison between breast cancer versus healthy controls, $ Comparison between thyroid cancer versus healthy