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. 2020 Sep 24;10:569985. doi: 10.3389/fonc.2020.569985

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Copyright © 2020 Ibrahim, Moss, Gray, Rojo, Burke, Schwertfeger, dos Santos and Machado.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Myeloid subclusters based on CD14 expression. (A) Graph depicts the number of cells in each myeloid cell cluster as a percentage at week 8 (dark blue) and week 16 (light blue). (B) UMAPs depict the distribution of CD14⁺ myeloid cells at week 8 (left) or week 16 (right), identifying 11 distinct myeloid clusters (MC 0–10) and their abundance at each timepoint. (C) Violin plots demonstrate the distribution of various genes in each myeloid cluster that are commonly expressed in macrophages (Adgre1, Cd68, Csfr1, Mafb, Cd14), monocytes (Ly6c2), other myeloid cells (S100a8), and dendritic cells (Flt3, Xcr1, Ccr7). (D) Dendrogram shows similarities among subclusters and enrichment for each cluster at week 8 or week 16. (E) Diffusion map for myeloid subclusters demonstrating a branch point at cluster 1, which represents Ly6c2+ monocytes.