Fig. 2.

Cross talk between lipid families. C1P is capable of activating PLA₂, which converts phospholipids to AA, or, PA to LPA. Ceramide can activate LPP₃, which hydrolyzes LPA to MAG. S1P can activate COX₂ to convert AA to PGH₂. AA, arachidonic acid; ATX, autotaxin COX₂, cyclooxygenase 2; CYP-450, cytochrome-P450; C1P, ceramide-1-phosphate; EETs, epoxyeicosatrienoic acids; LPC, lysosphatidylcholine; LPA, lysophosphatidic acid; LPP₃, lipid phosphate phosphatase 3; Lyso-PLD, lysophospolipase D; MAG, monoacylglycerol; NSmase, neutral sphingomyelinase; PA, phosphatidic acid; PGH₂, prostaglandin H₂; PGI₂, prostacyclin; PLA₂, phospholipase A₂; SM synthase, sphingomyelin synthase; SpK, sphingosine kinase; SpP, sphingosine phosphatase; S1P, sphingosine-1-phosphate; TXA₂, thromboxane.