Table 1.
Patient variables in dogs randomly assigned to receive either methadone (0.5 mg/kg) or hydromorphone (0.1 mg/kg) IV with electrocardiogram recordings obtained while awake (groups M and H) or while awake and during sevoflurane anesthesia following 15 min with end-tidal sevoflurane stabilized at 2.4% (groups MS and HS, respectively).
| Methadone | Hydromorphone | |||
|---|---|---|---|---|
| MS (n = 12) | M (n = 8) | HS (n = 12) | H (n = 8) | |
| Body weight (kg) | 21.4 ± 10.5 | 18.4 ± 9.2 | 16.7 ± 11.8 kg | 26.0 ± 18.4 |
| Age (year) | 3.2 ± 1.5 | 2.8 ± 2.0 | 2.0 ± 1.6 | 2.1 ± 1.5 |
| Breed | Golden Retriever | Mixed Breed Dog | Boston Terrier | Boxer |
| Pit Bull Terrier | French Bulldog | American Cocker Spaniel | Australian Shepherd | |
| Mixed Breed Dog | Mixed Breed Dog | Mixed Breed Dog | Collie | |
| Yorkshire Terrier | Corgi | Maltese | Great Dane | |
| Havanese | Mixed Breed Dog | Mixed Breed Dog | Mixed Breed Dog | |
| Labrador Retriever | Golden Retriever | Cavalier King Charles Spaniel | Pit Bull Terrier | |
| Mixed Breed Dog | Boxer | Mixed Breed Dog | Great Dane | |
| Boxer | Pit Bull Terrier | Mixed Breed Dog | Mixed Breed Dog | |
| Boston Terrier | Havanese | |||
| Samoyed | German Shepherd | |||
| Golden Retriever | Mixed Breed Dog | |||
| Australian Shepherd | Boxer | |||
| Propofol dose (mg/kg) | 3.6 ± 1.1 | – | 3.4 ± 1.1 | – |
| ETCO2 (mmHg [kPa]) | 35.8 ± 3.1 [4.8 ±0.4] | – | 38.3 ± 3.4 [5.1 ± 0.5] | – |
| ETsevo (%) | 2.40 ± 0.01 | – | 2.41 ± 0.01 | – |
| Sevoflurane duration (min) | 21.7 ± 3.0 | – | 20.1 ± 3.3 | – |